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Treatment > Community Level Interventions for Pre-eclampsia: Mozambique

CLIP Feasibility Study

The Feasibility Study in Mozambique was led by PIs Esperança Sevene and Khátia Munguambe. Additional investigators for the study in Mozambique include Clara Menendez, Eusebio Macete, Ariel Nhacolo, Charfudin Sacoor, Helena Boene and Abel Nhama.

Mozambique has successfully completed the Feasibility Study (10 October, 2014) including the baseline survey and launched the CLIP Definitive Trial in February 2015. The baseline data collection was carried by the Manhiça Health Research Centre (CISM), who has experience in conducting demographic and health surveillance for the past 19 years. The aim of the baseline study was to create a platform to provide reliable health, socio-demographic and geographic data for the implementation of a community intervention for the prevention and treatment of pre-eclampsia and eclampsia in 12 pre-selected communities in the Provinces of Maputo and Gaza. These areas were selected purposely to capture variety in rural/semi-rural characteristics, population density, access to and distance from main trading centres, and the presence or absence of referral centres. The baseline activities in Mozambique began in March 2014. The baseline study enabled the Mozambique team to pilot test the surveillance processes prior to the Trial. In the past year the Mozambique team has successfully completed their baseline household survey allowing sample size estimates to be confirmed. The estimated maternal mortality ratio (MMR) for the cluster areas was found to be 201/100,000 live births, which is lower than the World Bank estimate of 480 in 2013 and the Mozambican DHS 2011 estimate of 408. The mortality rate of women of reproductive age of 2.44 per 1000 women of reproductive age in the 12 clusters seems to be low in these communities where HIV prevalence is high and access to care is still a challenge. The mortality rate of women of reproductive age was not as high as in the rest of the country, where the rate is 5.71 (IDS, 2011). Neonatal mortality rate is 30.9 per 1000 live births, which is 30% lower than the national estimates.

CLIP Definitive Trial

The CLIP Trial in Mozambique does not include a Pilot phase. The 12-month rigorous Feasibility Study is designed to provide a robust understanding of the barriers to, facilitators for and solutions for the CLIP Definitive Trial. 

CLIP Definitive Trial effectively started on 24 February 2015, and ended on 24 February 2017.