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Objective 1: CAP study update (Nov 2017 - Jan 2018)

The CAP Study

Women with a history of pre-eclampsia in their most recent pregnancy who agreed to participate, received calcium 500mg daily or placebo from enrolment until they become pregnant, and up to 20 weeks of pregnancy.  All women received calcium 1500mg daily after 20 weeks as per WHO recommendations. The primary outcome is pre-eclampsia. 
 

CAP study progress

Since confidential presentation of preliminary results at the final PRE-EMPT meeting in London in October, we have been finalizing the analysis and preparing the main paper for submission. We have also added 3 publications to our list (see below), and undertake e-archiving of the study files.

Presentations at the PRE-EMPT and CoLab Annual Meetings: 

  • Hofmeyr GJ on behalf of the CAP study group. Calcium And Pregnancy (CAP) Trial. PRE-EMPT Sixth Annual Meeting, London, UK, 4 October 2017
  • Hofmeyr GJ on behalf of the CAP study group. Calcium in Pregnancy. 2017 Global Pregnancy Collaboration (CoLab) Membership Meeting, London, UK, 2 October 2017 
  • Cormick G. Obesity Worldwide: Different Mechanism in Different Populations? 2017 Global Pregnancy Collaboration (CoLab) Membership Meeting, London, UK, 2 October 2017 
  • Roberts J, Munjanja S. EMPOWER Project - Zimbabwe. 2017 Global Pregnancy Collaboration (CoLab) Membership Meeting, London, UK, 2 October 2017 

Recent publications:

Secondary analyses

We have a unique database of women with previous pre-eclampsia followed from before pregnancy and through the subsequent pregnancy, and encourage all our team and those from the wider PRE-EMPT community to come forward with proposals for secondary analyses of the data or further research using the archived biological samples.

The following secondary analyses are under consideration (lead author):

  • Comparison of maternal and perinatal outcomes in index pregnancy compared to outcomes in previous pregnancies (Sue Fawcus)
  • Predictors of pre-eclampsia (Simpiwe Mose)
  • The effects of calcium supplementation in relation to compliance (Eduardo Bergel and Gabriela Cormick)
  • Definitive study on effects of calcium on blood pressure in non-pregnant women (Mandisa Singata)
  • Urine studies: Validation of a strip protein:creatinine ratio test: effects of calcium supplementation on protein:creatinine and Calcium:creatinine ratios (Sarah Manyame, Stephen Munjanja and Jim Roberts)
  • Effects of calcium on weight in non-pregnant women (Gabriela Cormick)