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Microchimerism: Defining and redefining the prepregnancy context - A review.

TitleMicrochimerism: Defining and redefining the prepregnancy context - A review.
Publication TypeJournal Article
Year of Publication2017
AuthorsGammill, H, Harrington, W
JournalPlacenta
Volume60
Pagination130-133
Date Published2017 Dec
ISSN1532-3102
KeywordsChimerism, COLAB, Female, Fetus, Global Pregnancy Collaboration (CoLab), Humans, Malaria, Maternal-Fetal Exchange, Placenta Diseases, Pregnancy
Abstract

Bidirectional transplacental exchange characterizes human pregnancy. Cells exchanged between mother and fetus can durably persist as microchimerism and may have both short- and long-term consequences for the recipient. The amount, type, and persistence of microchimerism are influenced by obstetric characteristics, pregnancy complications, exposures to infection, and other factors. A reproductive-aged woman enters pregnancy harboring previously acquired microchimeric "grafts," which may influence her preconception health and her subsequent pregnancy outcomes. Many questions remain to be answered about microchimerism with broad-ranging implications. This review will summarize key aspects of this field of research and propose important questions to be addressed moving forward.

DOI10.1016/j.placenta.2017.08.071
Alternate JournalPlacenta
Citation Key564
PubMed ID28911790
PubMed Central IDPMC5718967
Grant ListK08 HD067221 / HD / NICHD NIH HHS / United States
T32 HD007233 / HD / NICHD NIH HHS / United States